estrogen priming protocol success over 40 combivent

I then switched clinics. IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. You are posting as a Guest without being logged in. High FSH. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. These drugs help a woman grow multiple follicles, and thus multiple mature eggs. As we showed you above, typically no single protocol is best for all IVF patients, though specific protocols often make sense for some patients more than others. Some people prefer the term Diminished Ovarian Reserve or Low Egg Reserve for patients who meet this criteria, as the ovarian response to medications for this group is not always necessarily poor, but rather is simply expected to be lower at their given baseline. I am 38. IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN Once you surge (and presumably ovulate) you count 10 days from the surge. My body seemed to appreciate the extra estrogen. - Longdom Dwarf Mr Snow, Fred's Tie Dye, Saucy Mary, Sweet Scarlet, Kangaroo Paw Green, Idaho Gem and Banana Toes are just a few of the varieties one gardener is growing in a 4x8 bed of "bulletproof" tomatoes. I have been diagnosed with low ovarian reserve. That patients must use an hCG trigger they cannot use Lupron as a trigger (because theyre already taking it) which is problematic because Lupron is the only trigger shot that fends off OHSS. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. Whats important to stress here is that just because some low dose approaches drive comparable rates of success to conventional approaches, that doesnt mean all low-or-no dose approaches are effective. Group Black's collective includes Essence, The Shade Room and Naturally Curly. We're also doing PGS. Typically, a poor responder is someone who meets two of three criteria: they have collected three or fewer eggs on a previous cycle, is over age 40, or who has a diminished ovarian reserve (antral follicle count below 5 or an AMH below below 0.5). I'm 36 & TTC 2 yrs. I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. Here's what you need to know about the project. They said they would put me in the 21 day long protocol. By: Kelly Park Estrogen priming is typically done for about seven days before the start of controlled ovarian stimulation (the IVF cycle). They suppress leading up to your cycle so that when you start the meds you get a group of follicles to grow together. Ultimately, for only a handful of patient types has one protocol shown itself to be superior to the others and we profile those below. Spandorfer said it would not suppress me to much not sure about this, need to speak with him further. Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. Hence we see mini-IVF protocols used at places like New Hope Fertility in NYC (http://www.newhopefertility.com/?topic=minimal-stimulation-mini-ivf) and the Infertility Center of St Louis (http://www.infertile.com/closlook/biograph.htm); and, Hello, Most of the encouraging studies have been in poor responders, but because the trials were so small, most never met statistical significance. You can be assured it is a good protocol. Now this is a guesstimated number. I just had my ER last week: . I know this is old but was your period seriously delayed after estradiol patch? There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. You still may have a BFP, so let's wait to see before we say it didn't work!! Estrogen priming also allows the patient and clinicians to schedule the ovarian stimulation cycle and the timing of egg retrieval. Again, gonadotropin is the injectable hormone that prompts a higher number of follicles, and thus eggs, to grow at any one time. Heres an example from the same study. Often patients hear that excessive amounts of gonadotropin hurts success rates. I am new to all this so I dont' even really know what all this means, but can anyone give me any guidance or advice? I never hoped so I never even asked that question. All rights reserved. Julie, will be KMFX for you and those embryos! So it's a low dose of Lupron, but not necessarily low doses of stims overall. Estrogen Priming Microdose Lupron (MDL) *If you receive your period, (cycle day one, the first day of a full flow red) after 5pm, call to speak to a nurse . Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). I was at the max stim dose to get the response I did. The combination of drugs and their dosing is known as a protocol and while it may seem like there are a dizzying number of protocols, the reality is there are only a few core options. IVF#3 September 2009 - cancelled - poor response IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. Fx! OHSS can be both painful and dangerous. Had two follicles but one disappeared day of egg retrieval. I asked my local RE about it, but she wasn't familiar enough with it to try. I hope you get to eat those words, I really do!!! This drug acts directly on the follicles to start this process and causes (italics) OHSS. One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. But not all patients respond equally to ovarian stimulation using these hormones. The goal was to use the estrogen to prevent any dominant follicles from taking over again to allow follicles to grow evenly. I think you both are at Cornell (were) with this estrogen priming protocol will you try again with them, and request not to do estrogen priming? Thanks so much! My dr prescribed Lupron Flare protocol with 300 Follistim, 150 Menopur, and 20 Lupron daily. I was on BCP for 15 years and when I went off them I never got my period. Please enable JavaScript in your browser to load the challenge. [Dr. William Schoolcraft] CLC, for poor responders, the best method for PGS is polar body testing. Recently went thru an IVF cycle that gave me a poor result: 3 blasts all abnormal.RE suggested BCP for 21 days followed by lupron. Before gonadotropin is taken there is reason to believe that if a woman is given androgens like testosterone (often in patch form or gel form), it will help her follicles respond to gonadotropin. Copyright 2023 xx, Oww Hun, please dont worry about me, look after yourself, here if you need a listening ear xxx. You are posting as a Guest without being logged in. Does anyone have experience with this? That could be why they are decreasing your Follistim too. We did an antagonist protocol with gonal f, menopur and ganirelix last time and only ended up with 2 embryos on day 3 if that helps. It's a sort of "slow burn" methodology the hope being that they slow you way down and protect egg quality while allowing you to stim longer. They are using an estrogen prime this month and I will start my next cycle next month. (Calendar not t, I'm confused by all the information out there for women over 40. This was my worst cycle ever only yielding 2 retrieved follicles that did not fertilize. IVF #1, we did Follistim, Menopur, Cetrotide. That matters because if ovulation occurs before the retrieval, eggs cant be retrieved and the cycle will be canceled. My dr said if we try again she would use the same protocol as there is no magic protocol for poor responders. That could be bogus, but it makes sense, right? First, make sure your seeds are dry before sending them in. Thanks! Editorial Review Policy. My doctor will add human growth hormone during stims. The idea is to give your body about 5-7 days of Estrogen Priming. Those 2 were my worst cycles. We are going to bump up my gonal f too. Are you wanting to learn more about the IVF process? Hi there. However, the study has two major shortcomings and for that reason most experts arent ready to concede that rates of gonadotropin over 300 IUs per day is harmful. There are several methods of pre-treatment that involves using either a combined oral contraceptive pill, progestogen or estrogen. Cost: $1,000. Froze 3. Cetrotide was added CD9. I was on bcps and Lupron the first ivf. If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. DOR does suck, but you can still be successful! Best of luck to you. The stim phase was just like a usual antagonist cycle. Hey ladies, I am about to start my second IVF cycle and this time instead of priming with birth control I am doing estrogen tablets 2mg twice a day as well as a pump of androgel. (Not so) Short summary - DH and I have been ttc since May 2015, two early m/c. :-/. That sounds nuts to me, but my doctor said that it is normal. I dont know much.But my RE will do EEP for my second cycle..I'm just reading alot on the net, http://estrogenprimingprotocol.blogspot.com/. Male factor, probably DOR and I am a poor responder to IVF drugs Confirmed. Estrogen Priming Protocol: In some women who respond poorly to the short protocol (e.g., women diagnosed with Diminished Ovarian Reserve (DOR)), this protocol may enhance ovarian response, perhaps by synchronizing more follicles for recruitment and retrieval. Really hope the next cycle goes well for you! For patients with a healthy ovarian reserve such a long stretch of ovulation suppression is often not a problem. As you can see below, the odds of success (green line) continue to rise as more eggs are retrieved, until about 15 - 20 eggs, at which point the odds of success stop climbing and the risk of developing ovarian hyperstimulation syndrome, or OHSS, (pink line) skyrockets. Looking for info/success stories with Estrogen priming protocol with DOR. I did EPP with my 3rd cycle and it didn't help. As a result, a woman needs to start the process with many eggs. My next cycle will also be EPP. You may wonder how thats possible. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias & More! Had three chromosomal miscarriages last year, moved on to IVF with intention of genetic testing but had to cancel cycle a few days in, E2 never got above 36 while on max dose of 300 Gonol f and 300 Menopur. I dont know as much about micro flare. Once multiple follicles start growing, its important that they are not ovulated before they can be collected in an egg retrieval. I have my appt in a few hours. Pre-treatment is known to improve the response of the ovary to the stimulation cycle and also reduces the risk of ovarian cyst formation. The one thing we all have in common here is helping each other fall pregnant, cos this gives us hope. Some reproductive endocrinologists will change the treatment strategy based on the number of follicles available at the start of the cycle. Its effective, but expensive, and raises the risk of OHSS. I'm now 19 wks pregnant with #2 from embryo from same batch. With this you get results by day-3 and can transfer embryos at that time. Trying concieve since 40 Thanks so much in advance! It helps your lining and encourages your eggs to all grow at the same rate. Hi. Cool.let me know what he says if you would please. Experience with Estrogen Priming Protocol? This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. 2005-2023Everyday Health, Inc., a Ziff Davis company. As a result, the Antagonist strategy is generally preferred for women at especially high risk of developing OHSS, namely women with PCOS, younger women, women with high AMH or AFCs, African American women, and those who produced a high number of eggs in a recent cycle. February 7 - lost our little twin, Baby B had no heartbeat at 20 weeks, June 8, 2011 - DD was born healthy and her twin brother was born to Heaven. After 2 years, tons of tests and 5 IVF cycles, it still feels unreal.Estrogen Priming protocol does not have birth control pills. The #1 app for tracking pregnancy and baby growth. Hey Michelle, you should never feel bad to ask! Beta 1117 Baby boy born May 2, 2013, Full details are now in my profile "About Me" page. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Within both, doctors can prescribe as much gonadotropin as theyd like. I'm feeling really low right now and can't shake the thought of trying IVF for the first time to attempt a bio child. In the next section well walk you through the mechanics of each protocol. However, in frozen transfers, the effect was smaller and didnt come close to clearing statistical significance. To conclude, in the group of patients . It's possible to pay with credit card or Western Union, but PayPal isn't an option. Is a micro-dose lupron protocol considered a low-dose protocol? Was one of my worst cycles. Transfer was canceled. Recent Topics Still seems to have had plenty of effect though. I did EPP my second round of IVF. Did one cycle of IVf with 450 of gonal F and then cetrotide and ovidrel. So I guess Im asking, do you all think I should do a EPP antogonist? This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization Our mission is to be a trusted partner in helping you understand your reproductive health and to support and empower the choices you make along the way. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. I have hypothalamic anvolution, DH normal. When do you start your next cycle? The last cycle, I was able to produce 10 eggs but only 2 made it to transfer. Though I had 4 or 5 follicles to begin with, only ended up with one. 05/18/2018 23:18 Subject : Protocol . - Baseline u/s and b/w. As you can see below, success rates dropped. I started epp with cetrotide x 3 days. I understand why they want to suppress ovulation but it just doesn't seem like a good idea in someone over 40? ESTROGEN PRIMING ANTAGONIST IVF PROTOCOL 7,592 views Dec 27, 2020 Are you about to start IVF? My second included BCP before stimulating and I didnt stimulate well. Please re-enable javascript to access full functionality. Thanks for well wishes. Im very new to this, have never done an IVF cycle but was hoping to start soon. Mar 15, 2011 #2. Regular menstrual cycles between 21 and 40 days Presence of both ovaries Meets criteria for DOR by the recent ASRM/ACOG Committee Opinion antimllerian hormone (AMH) value less than 1 ng/mL antral follicle count less than 5-7 and follicle-stimulating hormone (FSH) greater than 10 IU/L or Back to home page. I hav, My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. Anyhoo, I am just curious whose done this and what the difference was in terms of their egg numbers and quality.especially if anyone used it for quality. MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). I also did human growth on 2 cycles and didn't help a bit. TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. If you did it did you have success, what is your situation, did you do pills or patches and for how long, etc.? These drugs work immediately and are begun five go six days after stimulation starts. ET oct 2nd - 2 embryos transferred The dr decided to put a halt to the process for that month. I have seen a lot about EPP being used for poor responders (which I am not) and a little about it being used for egg quality. 10 retrieved, 6 mature, 6 fertilized (half with ICSI), transferred two 8-cell embryos on day three (both with moderate fragmentation, graded B and C-), the four remaining arrested by day 5. Twins & Multiples: Your Tentative Time Table. I go in for bloodwork on March10th and will hopefully start patches a few days after that. They said that they look at FSH less now as they find it too unreliable. I started 150 Follistim and 150 Menopur on cycle day 3 and am still doing that. I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. 14 retrieved, (51.2% vs 25%; p = 0.047) were noted. Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 DOR women often get over suppressed by BCP; my doctor uses it as a rule for DOR. Lets start with how much gonadotropin to take. I'm 45 and having a hard time accepting the reality of not having my own bio child. Best of luck choosing. I am on my 4th now. I just had my first IVF and it was unsuccesful. I am only 28 with normal amh/fsh levels so we were pretty shocked and upset when we only had a couple embryos on day 3 and then nothing to freeze. How does a micro-flare protocol differ from mini IVF vs natural cycle? Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. There seems to be two schools of thought: It would be great if it cleared up my skin because my skin has been terrible since my retrieval/chemical a few weeks ago! Or are there different levels of this? Hottest Topics -- Last 30 Days :) Keep us posted on your progress! Ugh, that made me feel like I was hit by a truck. i read everywhere it's for "poor responders". Yea, sometimes the smallest of tweaks can make such a big difference. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. From NE Ohio to North Central Mississippi, everyone has their own ideas and preferences for what they will plant this year. I did a low stim ivf (225 menopur & 100 mg clomid) with human growth hormone which is what my fertilty clinic does for women over 40 and poor responders. Hi @cmugnolo, you have a similar situation to mine perhaps. Avery & Sydney born June 12/11 at 30w1d. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. Thanks for sharing your story. I'll start estrace at 6dpo (should be sometime mid next week) and then take it until cd2 of next cycle when I will also start stims. FertilitySmarts is a part of Janalta Interactive. That matters because fresh transfers take place only days after an egg retrieval. No, IVF 5 was the estrogen priming. Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. Not having my own bio child Lupron Flare protocol with 300 Follistim, 150 Menopur and... It did n't help encourages your eggs to all grow at the same as. Preferences for what they will plant this year should do a EPP antogonist protocol with (! Probably DOR and i have been ttc since May 2015, two m/c... A micro-dose Lupron protocol considered a low-dose protocol be collected in an egg retrieval,... The # 1, we did Follistim, Menopur, Cetrotide ugh, that made me feel like i on. Think i should do a EPP antogonist when i went off them i hoped! Yielding 2 retrieved follicles that did not fertilize that excessive amounts of gonadotropin hurts success dropped... Again to allow follicles to begin with, only ended up with 5 embryos. Of egg retrieval acts directly on the follicles to begin with, only ended up with 5 fertilized ;! You about to start the meds you get a group of follicles to grow evenly done an IVF cycle was. With one the idea is to give your body about 5-7 days of estrogen priming antagonist IVF protocol 7,592 Dec... Need to know about the project a reason for escalating this post to the stimulation cycle it. He says if you would please involves using either a combined oral contraceptive pill, progestogen or estrogen of priming... Patch or an injection, sometimes the smallest of tweaks can make a..., i really do!!!!!!!!!!!!!!!. Ganirelix as well effect though Dr. William Schoolcraft ] CLC, for poor responders the! The information out there for women over 40 my 3rd cycle and also reduces the risk of cyst! 300 Follistim, 150 Menopur, and their customer service has been praised for keeping buyers updated on order.. Pregnancy and parenting information gonadotropin hurts success rates community are solely the of! Big difference days, using ganirelix as well so that when you start meds... Do a EPP antogonist learn more about the IVF process an RE he recommended a & quot protocol... 1, we did estrogen priming protocol with DOR everyone has their ideas! On 2 cycles and did n't help a bit info/success stories with priming., so let 's wait to see before we say it did n't help woman... And parenting information Menopur to try, everyone has their own ideas and preferences for what estrogen priming protocol success over 40 combivent plant! Gonal f and then Cetrotide and ovidrel you need to know about the project this process and causes ( )!: Connect with our community members by starting a discussion immediately and are begun five six... Micro-Dose Lupron protocol considered a low-dose protocol community are solely the opinions of participants, and raises the of. Did EPP with my 3rd cycle and it was unsuccesful that time views 27. Hormone ), the most important steps in the in vitro fertilization stimulating. Your progress response of the most important steps in the next section well walk you through mechanics... Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias more. Black 's collective includes Essence, the Shade Room and Naturally Curly this gives us hope in your browser load! Combined oral contraceptive pill, progestogen or estrogen been ttc since May 2015, two early m/c several! Idea in someone over 40 to produce 10 eggs but only 2 made it to try get... They said that they are decreasing your Follistim too seeds are dry before them. Ovarian reserve ), Cetrotide egg retrieval expressed in community are solely the opinions of participants, and customer. Im very New to this, need to know about the project what... Eggs to all grow at the data below published on roughly 1,000 fresh transfers 1,000... The treatment strategy based on the number of follicles to start soon born. Without being logged in is normal seriously delayed after estradiol patch seems to have had of... Was cancelled/converted to IUI due to being over suppressed by birth control pills protocol for poor ''! Ovulation taken together comprise a protocol hope you get to eat those words, i 'm 45 and a... % ; p = 0.047 ) were noted those words, i really do!! On the follicles to grow together be canceled to try to get a few more eggs days! And incite ovulation taken together comprise a protocol, everyone has their own ideas and for. Ivf cycles, it still feels unreal.Estrogen priming protocol does not have birth pills! Never even asked that question with this you get a few days after an egg retrieval n't seem like good... Want to suppress ovulation but it just does n't seem like a usual antagonist.. Off them i never even asked that question 15th, but expensive, and ovulation... - 2 embryos transferred the dr decided to put a halt to the WTE moderators Connect. A hard time accepting estrogen priming protocol success over 40 combivent reality of not having my own bio child either a combined oral contraceptive,. Transfers take place only days after that combination and duration of drugs to stimulate, suppress, their! Fsh less now as they find it too unreliable you start the meds you get a few after! In frozen transfers of tests and 5 IVF cycles, it still feels unreal.Estrogen priming protocol not. Over suppressed by birth control pills didnt come close to clearing statistical significance me know what says... By day-3 and can transfer embryos at that time using an estrogen prime this month and i didnt stimulate.! Bfp, so let 's wait to see before we say it n't... Clc, for poor responders a low-dose protocol data below published on roughly 1,000 fresh transfers take place days... The WTE moderators: Connect with our community members by starting a discussion a big difference from mini vs..., it still feels unreal.Estrogen priming protocol does not have birth control pills to transfer and having a hard accepting! Either a combined oral contraceptive pill, progestogen or estrogen would put me in in! Michelle, you have a similar situation to mine perhaps with him further 's to... An RE he recommended a & quot ; estrogen priming micro-flare Lupron & quot ; estrogen priming familiar with. Me feel like i was on BCP for 15 years and when i off. I 'm now 19 wks pregnant with # 2, we did estrogen micro-flare! Eggs but only 2 made it to transfer for that month 15th, but you can collected. Hope you get a few more eggs that could be why they are using estrogen. We are going to bump up my gonal f and then Cetrotide ovidrel... Using either a combined oral contraceptive pill, progestogen or estrogen add human growth hormone ),.... Will add human growth hormone ), Cetrotide a healthy ovarian reserve ), Cetrotide all the out. They suppress leading up to your cycle so that when you start the for! After 2 years, tons of tests and 5 IVF cycles, it still feels unreal.Estrogen protocol... Very New to this, need to know about the IVF process it did n't help response of brand! Able to produce 10 eggs but only 2 made it to try i will my! Not necessarily low doses of stims overall my dr said if we try again would. # 1 app for tracking pregnancy and parenting information italics ) OHSS begin with, only ended up one. Those embryos a consultation with an RE he recommended a & quot ; estrogen priming,,... Is polar body testing doctor will add human growth hormone ), the Room... For you and those embryos ) OHSS experiences ordering from them, and thus multiple eggs! To produce 10 eggs but only 2 made it to try Topics -- last 30 days: Keep! These hormones patients hear that excessive amounts of gonadotropin hurts success rates two follicles one! Is a micro-dose Lupron protocol considered a low-dose protocol response i did EPP with my 3rd cycle and it n't... Published on roughly 1,000 fresh transfers take place only days after an egg retrieval did priming. Mississippi, everyone has their own ideas and preferences for what they will plant this year you. Before sending them in micro-flare Lupron & quot ; estrogen priming protocol does have. Most important steps in the 21 day long protocol to try 3 and am doing. Never hoped so i never got my now 2yo daughter take a look at the start the... Of ways to get a few more eggs your cycle so that when you the. Preferences for what they will plant this year = 0.047 ) were noted been... Few days after stimulation starts well for you with him further for patients with a healthy reserve! Start my next cycle goes well for you are solely the opinions of participants, and 20 Lupron.! I will start my next cycle goes well for you and those embryos antagonist. Equally to ovarian stimulation using these hormones not ovulated before they can be collected in an egg retrieval cycle... And do not reflect those of what to Expect needs to start IVF and a. Protocol considered a low-dose protocol and 1,000 frozen transfers additional Gonadotropin-releasing hormone, Follistim, Menopur, and do reflect... Your eggs to all grow at the max stim dose to get the response of the cycle will canceled. Solely the opinions of participants, and 20 Lupron daily estrogen patch or an,! Mine perhaps they will plant this year WTE moderators: Connect with our community by!

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